Abstract
A novel series of potent 2-aryl pyrido[2,3-d]pyrimidine mGlu5 receptor antagonists are described. The synthesis and pharmacological activities of these analogs are discussed.
MeSH terms
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Animals
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CHO Cells
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Calcium / metabolism
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Cricetinae
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Cricetulus
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Cyclooxygenase 2 Inhibitors / therapeutic use
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Excitatory Amino Acid Antagonists / chemical synthesis*
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Excitatory Amino Acid Antagonists / pharmacology*
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Indicators and Reagents
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Joints / pathology
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Lactones / therapeutic use
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Osteoarthritis / chemically induced
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Osteoarthritis / drug therapy
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Osteoarthritis / pathology
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Pyridines / chemistry
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Pyridines / pharmacology
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Pyrimidines / chemical synthesis*
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Pyrimidines / pharmacology*
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Rats
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Receptor, Metabotropic Glutamate 5
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Receptors, Metabotropic Glutamate / antagonists & inhibitors*
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Structure-Activity Relationship
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Sulfones / therapeutic use
Substances
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Cyclooxygenase 2 Inhibitors
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Excitatory Amino Acid Antagonists
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Indicators and Reagents
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Lactones
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Pyridines
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Pyrimidines
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Receptor, Metabotropic Glutamate 5
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Receptors, Metabotropic Glutamate
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Sulfones
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rofecoxib
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6-methyl-2-(phenylethynyl)pyridine
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Calcium